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Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A.


ABSTRACT: As part of a continuing program to identify novel treatments for neglected parasitic diseases, the Panama International Cooperative Biodiversity Group (ICBG) program has been investigating the antimalarial potential of secondary metabolites from Panamanian marine cyanobacteria. From over 60 strains of cyanobacteria evaluated in our biological screens, the organic extract of a Schizothrix species from a tropical reef near Piedras Gallinas (Caribbean coast of Panama) showed potent initial antimalarial activity against the W2 chloroquine-resistant strain of Plasmodium falciparum. Bioassay-guided fractionation followed by 2D NMR analysis afforded the planar structure of a new and highly functionalized linear peptide, gallinamide A. Subsequent degradation and derivatization methods were used to determine the absolute configuration at most stereogenic centers in this unusual new metabolite.

SUBMITTER: Linington RG 

PROVIDER: S-EPMC2760338 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature

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Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A.

Linington Roger G RG   Clark Benjamin R BR   Trimble Erin E EE   Almanza Alejandro A   Ureña Luis-David LD   Kyle Dennis E DE   Gerwick William H WH  

Journal of natural products 20090101 1


As part of a continuing program to identify novel treatments for neglected parasitic diseases, the Panama International Cooperative Biodiversity Group (ICBG) program has been investigating the antimalarial potential of secondary metabolites from Panamanian marine cyanobacteria. From over 60 strains of cyanobacteria evaluated in our biological screens, the organic extract of a Schizothrix species from a tropical reef near Piedras Gallinas (Caribbean coast of Panama) showed potent initial antimala  ...[more]

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