Ontology highlight
ABSTRACT:
SUBMITTER: Oku N
PROVIDER: S-EPMC3850515 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20100801 30
Enigmazole A (1), a novel phosphate-containing macrolide, was isolated from a Papua New Guinea collection of the marine sponge Cinachyrella enigmatica. The structure of 1, including the absolute stereochemistry at all eight chiral centers, was determined by a combination of spectroscopic analyses and a series of microscale chemical derivatization studies. Compound 1 is comprised of an 18-membered phosphomacrolide that contains an embedded exomethylene-substituted tetrahydropyran ring and an acyc ...[more]