Ontology highlight
ABSTRACT:
SUBMITTER: Zimmer M
PROVIDER: S-EPMC2760494 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Zimmer Manuel M Gray Jesse M JM Pokala Navin N Chang Andy J AJ Karow David S DS Marletta Michael A MA Hudson Martin L ML Morton David B DB Chronis Nikos N Bargmann Cornelia I CI
Neuron 20090301 6
Homeostatic sensory systems detect small deviations in temperature, water balance, pH, and energy needs to regulate adaptive behavior and physiology. In C. elegans, a homeostatic preference for intermediate oxygen (O2) levels requires cGMP signaling through soluble guanylate cyclases (sGCs), proteins that bind gases through an associated heme group. Here we use behavioral analysis, functional imaging, and genetics to show that reciprocal changes in O2 levels are encoded by sensory neurons that e ...[more]