Ontology highlight
ABSTRACT:
SUBMITTER: Pellicena P
PROVIDER: S-EPMC516465 | biostudies-literature | 2004 Aug
REPOSITORIES: biostudies-literature
Pellicena Patricia P Karow David S DS Boon Elizabeth M EM Marletta Michael A MA Kuriyan John J
Proceedings of the National Academy of Sciences of the United States of America 20040823 35
Soluble guanylate cyclases are nitric oxide-responsive signaling proteins in which the nitric oxide sensor is a heme-binding domain of unknown structure that we have termed the heme-NO and oxygen binding (H-NOX) domain. H-NOX domains are also found in bacteria, either as isolated domains, or are fused through a membrane-spanning region to methyl-accepting chemotaxis proteins. We have determined the crystal structure of an oxygen-binding H-NOX domain of one such signaling protein from the obligat ...[more]