Extracellular redox modulation by regulatory T cells.
Ontology highlight
ABSTRACT:
SUBMITTER: Yan Z
PROVIDER: S-EPMC2760945 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Publications
Extracellular redox modulation by regulatory T cells.
Yan Zhonghua Z Garg Sanjay K SK Kipnis Jonathan J Banerjee Ruma R
Nature chemical biology 20090830 10
We demonstrate that the mechanism of redox remodeling during mouse T-cell activation involves secretion of glutathione by dendritic cells and its subsequent cleavage to cysteine. Extracellular cysteine accumulation results in a lower redox potential, which is conducive to proliferation, and changes the net redox status of exofacial protein domains. Regulatory T cells inhibit this redox metabolite signaling pathway, which represents a previously unrecognized mechanism for immunosuppression of eff ...[more]
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