Ontology highlight
ABSTRACT:
SUBMITTER: Adams GB
PROVIDER: S-EPMC2761017 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Adams Gregor B GB Alley Ian R IR Chung Ung-Il UI Chabner Karissa T KT Jeanson Nathaniel T NT Lo Celso Cristina C Marsters Emily S ES Chen Min M Weinstein Lee S LS Lin Charles P CP Kronenberg Henry M HM Scadden David T DT
Nature 20090325 7243
Haematopoietic stem and progenitor cells (HSPCs) change location during development and circulate in mammals throughout life, moving into and out of the bloodstream to engage bone marrow niches in sequential steps of homing, engraftment and retention. Here we show that HSPC engraftment of bone marrow in fetal development is dependent on the guanine-nucleotide-binding protein stimulatory alpha subunit (Galpha(s)). HSPCs from adult mice deficient in Galpha(s) (Galpha(s)(-/-)) differentiate and und ...[more]