Ontology highlight
ABSTRACT:
SUBMITTER: Mendez-Ferrer S
PROVIDER: S-EPMC3146551 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Méndez-Ferrer Simón S Michurina Tatyana V TV Ferraro Francesca F Mazloom Amin R AR Macarthur Ben D BD Lira Sergio A SA Scadden David T DT Ma'ayan Avi A Enikolopov Grigori N GN Frenette Paul S PS
Nature 20100801 7308
The cellular constituents forming the haematopoietic stem cell (HSC) niche in the bone marrow are unclear, with studies implicating osteoblasts, endothelial and perivascular cells. Here we demonstrate that mesenchymal stem cells (MSCs), identified using nestin expression, constitute an essential HSC niche component. Nestin(+) MSCs contain all the bone-marrow colony-forming-unit fibroblastic activity and can be propagated as non-adherent 'mesenspheres' that can self-renew and expand in serial tra ...[more]