Ontology highlight
ABSTRACT:
SUBMITTER: Wan L
PROVIDER: S-EPMC2761258 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Wan Lin L Sun Kelian K Ding Qi Q Cui Yuehua Y Li Ming M Wen Yalu Y Elston Robert C RC Qian Minping M Fu Wenjiang J WJ
Nucleic acids research 20090707 17
Affymetrix SNP arrays have been widely used for single-nucleotide polymorphism (SNP) genotype calling and DNA copy number variation inference. Although numerous methods have achieved high accuracy in these fields, most studies have paid little attention to the modeling of hybridization of probes to off-target allele sequences, which can affect the accuracy greatly. In this study, we address this issue and demonstrate that hybridization with mismatch nucleotides (HWMMN) occurs in all SNP probe-se ...[more]