Ontology highlight
ABSTRACT:
SUBMITTER: Juliano JJ
PROVIDER: S-EPMC2761972 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Juliano Jonathan J JJ Ariey Frederic F Sem Rithy R Tangpukdee Noppadon N Krudsood Srivicha S Olson Carol C Looareesuwan Sornchai S Rogers William O WO Wongsrichanalai Chansuda C Meshnick Steven R SR
The Journal of infectious diseases 20090801 4
Most trials of antimalarials occur in areas in which reinfections are possible. For Plasmodium falciparum, reinfections are distinguished from recrudescences by polymerase chain reaction analysis of 3 polymorphic genes. However, the validity of this approach has never been rigorously tested. We tested for misclassification in 6 patients from clinical trials in Thailand and Cambodia who were classified as being reinfected by the standard polymerase chain reaction protocol. Using heteroduplex trac ...[more]