Ontology highlight
ABSTRACT:
SUBMITTER: Chi X
PROVIDER: S-EPMC2762206 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Developmental cell 20090801 2
While the genetic control of renal branching morphogenesis has been extensively described, the cellular basis of this process remains obscure. GDNF/RET signaling is required for ureter and kidney development, and cells lacking Ret are excluded from the tips of the branching ureteric bud in chimeric kidneys. Here, we find that this exclusion results from earlier Ret-dependent cell rearrangements in the caudal Wolffian duct, which generate a specialized epithelial domain that later emerges as the ...[more]