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ASH2L controls ureteric bud morphogenesis via regulation of RET/GFRA1 signaling activity [CUT&Tag]

ABSTRACT: To elucidate the role of H3K4 methylation in metanephros development, we selectively inactivated ASH2L, core subunit of the COMPASS complex in mice UB lineage. We then performed histone H3K4me3 modification landscape profiling of the control (Hoxb7Cre-GFP+,Ash2l F/+) and mutant (Hoxb7Cre-GFP+,Ash2l F/F) FACS-sorted UB lineage cells at E16.5 by CUT&Tag-seq.

ORGANISM(S): Mus musculus

PROVIDER: GSE208273 | GEO | 2023/01/18

REPOSITORIES: GEO

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ASH2L controls ureteric bud morphogenesis via regulation of RET/GFRA1 signaling activity [RNA-seq]

Project description:To elucidate the role of H3K4 methylation in metanephros development, we selectively inactivated ASH2L, core subunit of the COMPASS complex in mice UB lineage. We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 different FACS-sorted UB lineage cells at E16.5 of the control and cKO mouse embryos.

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ASH2L controls ureteric bud morphogenesis via regulation of RET/GFRA1 signaling activity

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ASH2L controls ureteric bud morphogenesis via regulation of RET/GFRA1 signaling activity

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