Ontology highlight
ABSTRACT:
SUBMITTER: Wang P
PROVIDER: S-EPMC2763324 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Wang Peng P Zou Fangdong F Zhang Xiaodong X Li Hua H Dulak Austin A Tomko Robert J RJ Lazo John S JS Wang Zhenghe Z Zhang Lin L Yu Jian J
Cancer research 20091013 20
microRNAs (miRNA) are small noncoding RNAs that participate in diverse biological processes by suppressing target gene expression. Altered expression of miR-21 has been reported in cancer. To gain insights into its potential role in tumorigenesis, we generated miR-21 knockout colon cancer cells through gene targeting. Unbiased microarray analysis combined with bioinformatics identified cell cycle regulator Cdc25A as a miR-21 target. miR-21 suppressed Cdc25A expression through a defined sequence ...[more]