The S100P/RAGE signaling pathway regulates expression of microRNA-21 in colon cancer cells.
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ABSTRACT:
SUBMITTER: Mercado-Pimentel ME
PROVIDER: S-EPMC4582666 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
The S100P/RAGE signaling pathway regulates expression of microRNA-21 in colon cancer cells.
Mercado-Pimentel Melania E ME Onyeagucha Benjamin C BC Li Qing Q Pimentel Angel C AC Jandova Jana J Nelson Mark A MA
FEBS letters 20150717 18
S100P signaling through the receptor for advanced glycation end-products (RAGE) contributes to colon cancer invasion and metastasis, but the mechanistic features of this process are obscure. Here, we investigate whether activation of S100P/RAGE signaling regulates oncogenic microRNA-21 (miR-21). We show that exogenous S100P up-regulates miR-21 levels in human colon cancer cells, whereas knockdown of S100P results in a decrease of miR-21. Furthermore, blockage of RAGE with anti-RAGE antibody supp ...[more]
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