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No association of DAPK1 and ABCA2 SNPs on chromosome 9 with Alzheimer's disease.

ABSTRACT: Recently genetic variation in the DAPK1 and ABCA2 genes has been reported to be associated with late- and early-onset Alzheimer's disease (AD), respectively. We examined the most significant two single-nucleotide polymorphisms (SNPs) in DAPK1 in a large case-control cohort of late-onset subjects and matched controls and one of the most significant SNPs in ABCA2 in a small set of early-onset subjects as well. We did not detect associations with AD for any variation.

SUBMITTER: Minster RL

PROVIDER: S-EPMC2763561 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature

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No association of DAPK1 and ABCA2 SNPs on chromosome 9 with Alzheimer's disease.

Minster Ryan L RL DeKosky Steven T ST Kamboh M Ilyas MI

Neurobiology of aging 20080311 11

Recently genetic variation in the DAPK1 and ABCA2 genes has been reported to be associated with late- and early-onset Alzheimer's disease (AD), respectively. We examined the most significant two single-nucleotide polymorphisms (SNPs) in DAPK1 in a large case-control cohort of late-onset subjects and matched controls and one of the most significant SNPs in ABCA2 in a small set of early-onset subjects as well. We did not detect associations with AD for any variation. ...[more]

PMID: 18336955

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