Ontology highlight
ABSTRACT:
SUBMITTER: Zeev-Ben-Mordehai T
PROVIDER: S-EPMC2764065 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Zeev-Ben-Mordehai Tzviya T Mylonas Efstratios E Paz Aviv A Peleg Yoav Y Toker Lilly L Silman Israel I Svergun Dmitri I DI Sussman Joel L JL
Biophysical journal 20091001 8
Amalgam (Ama) is a secreted neuronal adhesion protein that contains three tandem immunoglobulin domains. It has both homophilic and heterophilic cell adhesion properties, and is required for axon guidance and fasciculation during early stages of Drosophila development. Here, we report its biophysical characterization and use small-angle x-ray scattering to determine its low-resolution structure in solution. The biophysical studies revealed that Ama forms dimers in solution, and that its secondar ...[more]