Ontology highlight
ABSTRACT:
SUBMITTER: Solito R
PROVIDER: S-EPMC2764262 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Solito Raffaella R Corti Federico F Fossati Silvia S Mezhericher Emiliya E Donnini Sandra S Ghiso Jorge J Giachetti Antonio A Rostagno Agueda A Ziche Marina M
Experimental cell research 20081119 3
Single point mutations of the amyloid precursor protein generate Abeta variants bearing amino acid substitutions at positions 21-23. These mutants are associated with distinct hereditary phenotypes of cerebral amyloid angiopathy, manifesting varying degrees of tropism for brain vessels, and impaired microvessel remodeling and angiogenesis. We examined the differential effects of E22Q (Dutch), and E22G (Arctic) variants in comparison to WT Abeta on brain endothelial cell proliferation, angiogenic ...[more]