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Architects of assembly: roles of Flaviviridae non-structural proteins in virion morphogenesis.

ABSTRACT: Viruses of the Flaviviridae family, including hepatitis C, dengue and bovine viral diarrhoea, are responsible for considerable morbidity and mortality worldwide. Recent advances in our understanding of virion assembly have uncovered commonalities among distantly related members of this family. We discuss the emerging hypothesis that physical virion components are not alone in forming the infectious particle, but that non-structural proteins are intimately involved in orchestrating morphogenesis. Pinpointing the roles of Flaviviridae proteins in virion production could reveal new avenues for antiviral therapeutics.

SUBMITTER: Murray CL

PROVIDER: S-EPMC2764292 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature

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Architects of assembly: roles of Flaviviridae non-structural proteins in virion morphogenesis.

Murray Catherine L CL Jones Christopher T CT Rice Charles M CM

Nature reviews. Microbiology 20080901 9

Viruses of the Flaviviridae family, including hepatitis C, dengue and bovine viral diarrhoea, are responsible for considerable morbidity and mortality worldwide. Recent advances in our understanding of virion assembly have uncovered commonalities among distantly related members of this family. We discuss the emerging hypothesis that physical virion components are not alone in forming the infectious particle, but that non-structural proteins are intimately involved in orchestrating morphogenesis. ...[more]

PMID: 18587411

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