The secreted Helicobacter cysteine-rich protein A causes adherence of human monocytes and differentiation into a macrophage-like phenotype.
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ABSTRACT:
SUBMITTER: Dumrese C
PROVIDER: S-EPMC2764743 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
The secreted Helicobacter cysteine-rich protein A causes adherence of human monocytes and differentiation into a macrophage-like phenotype.
Dumrese Claudia C Slomianka Lutz L Ziegler Urs U Choi Sung Sook SS Kalia Awdhesh A Fulurija Alma A Lu Wei W Berg Douglas E DE Benghezal Mohammed M Marshall Barry B Mittl Peer R E PR
FEBS letters 20090424 10
Helicobacter pylori genomes typically contain 8 or 9 genes that code for secreted and highly disulfide-bridged proteins designated Helicobacter cysteine-rich proteins (Hcp). Here we show that HcpA (hp0211) but not HcpC (hp1098) triggers the differentiation of human myeloid Thp1 monocytes into macrophages. Small amounts of HcpA cause the transition of round-shaped monocytes into cells with star-like morphologies, adherence to the culture dish surface, phagocytosis of opsonized fluorescent microsp ...[more]
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