Processed pseudogenes: the 'fossilized footprints' of past gene expression.
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ABSTRACT:
SUBMITTER: Podlaha O
PROVIDER: S-EPMC2764836 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Publications
Processed pseudogenes: the 'fossilized footprints' of past gene expression.
Podlaha Ondrej O Zhang Jianzhi J
Trends in genetics : TIG 20090930 10
Although our knowledge of the genes and genomes of extinct organisms is improving as a result of progress in sequencing ancient DNA, the transcriptomes of extinct organisms remain inaccessible, owing to the rapid degradation of messenger RNA after death. We provide empirical evidence that gene expression levels in the reproductive tissues of mice and during early mouse development correlate highly with the rate of inherited retroposition: the source of processed pseudogenes in the genome. Thus, ...[more]
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