Ontology highlight
ABSTRACT:
SUBMITTER: Kurenova EV
PROVIDER: S-EPMC2765121 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Kurenova Elena V EV Hunt Darell L DL He Dihua D Magis Andrew T AT Ostrov David A DA Cance William G WG
Journal of medicinal chemistry 20090801 15
FAK is a tyrosine kinase that functions as a key orchestrator of signals leading to invasion and metastasis. Since FAK interacts directly with a number of critical proteins involved in survival signaling in tumor cells, we hypothesized that targeting a key protein-protein interface with druglike small molecules was a feasible strategy for inhibiting tumor growth. In this study, we targeted the protein-protein interface between FAK and VEGFR-3 and identified compound C4 (chloropyramine hydrochlor ...[more]