Ontology highlight
ABSTRACT:
SUBMITTER: Song Y
PROVIDER: S-EPMC2765255 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Song Yongcheng Y Lin Fu-Yang FY Yin Fenglin F Hensler Mary M Rodrígues Poveda Carlos A CA Mukkamala Dushyant D Cao Rong R Wang Hong H Morita Craig T CT González Pacanowska Dolores D Nizet Victor V Oldfield Eric E
Journal of medicinal chemistry 20090201 4
Staphylococcus aureus produces a golden carotenoid virulence factor called staphyloxanthin (STX), and we report here the inhibition of the enzyme, dehydrosqualene synthase (CrtM), responsible for the first committed step in STX biosynthesis. The most active compounds are halogen-substituted phosphonosulfonates, with K(i) values as low as 5 nM against the enzyme and IC(50) values for STX inhibition in S. aureus as low as 11 nM. There is, however, only a poor correlation (R(2) = 0.27) between enzy ...[more]