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Highly enantioselective hydrogenation of enamides catalyzed by chiral phosphoric acids.

ABSTRACT: A highly enantioselective hydrogenation of enamides catalyzed by a dual chiral-achiral acid system was developed. By employing a substoichiometric amount of a chiral phosphoric acid and acetic acid, catalyst loadings as low as 1 mol % of the chiral catalyst were sufficient to provide excellent yield and enantioselectivity of the reduction product.

SUBMITTER: Li G

PROVIDER: S-EPMC2765520 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature

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Highly enantioselective hydrogenation of enamides catalyzed by chiral phosphoric acids.

Li Guilong G Antilla Jon C JC

Organic letters 20090301 5

A highly enantioselective hydrogenation of enamides catalyzed by a dual chiral-achiral acid system was developed. By employing a substoichiometric amount of a chiral phosphoric acid and acetic acid, catalyst loadings as low as 1 mol % of the chiral catalyst were sufficient to provide excellent yield and enantioselectivity of the reduction product. ...[more]

PMID: 19199770

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