Unknown

Dataset Information

0

Facile synthesis of stapled, structurally reinforced peptide helices via a photoinduced intramolecular 1,3-dipolar cycloaddition reaction.


ABSTRACT: We report the first use of a photoinduced 1,3-dipolar cycloaddition reaction in "stapling" peptide sidechains to reinforce a model peptide helical structure with moderate to excellent yields; the resulting pyrazoline "staplers" exhibit unique fluorescence useful in a cell permeability study.

SUBMITTER: Madden MM 

PROVIDER: S-EPMC2765658 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Facile synthesis of stapled, structurally reinforced peptide helices via a photoinduced intramolecular 1,3-dipolar cycloaddition reaction.

Madden Michael M MM   Rivera Vera Claudia I CI   Song Wenjiao W   Lin Qing Q  

Chemical communications (Cambridge, England) 20090813 37


We report the first use of a photoinduced 1,3-dipolar cycloaddition reaction in "stapling" peptide sidechains to reinforce a model peptide helical structure with moderate to excellent yields; the resulting pyrazoline "staplers" exhibit unique fluorescence useful in a cell permeability study. ...[more]

Similar Datasets

| S-EPMC2587417 | biostudies-literature
| S-EPMC4126266 | biostudies-literature
| S-EPMC6720653 | biostudies-literature
| S-EPMC9073340 | biostudies-literature
| S-EPMC6270352 | biostudies-literature
| S-EPMC5839603 | biostudies-literature
| S-EPMC3164318 | biostudies-literature
| S-EPMC3252871 | biostudies-literature
| S-EPMC10370549 | biostudies-literature
| S-EPMC10946888 | biostudies-literature