Ontology highlight
ABSTRACT:
SUBMITTER: Figueroa ME
PROVIDER: S-EPMC2765680 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Figueroa Maria E ME Skrabanek Lucy L Li Yushan Y Jiemjit Anchalee A Fandy Tamer E TE Paietta Elisabeth E Fernandez Hugo H Tallman Martin S MS Greally John M JM Carraway Hetty H Licht Jonathan D JD Gore Steven D SD Melnick Ari A
Blood 20090803 16
Increasing evidence shows aberrant hypermethylation of genes occurring in and potentially contributing to pathogenesis of myeloid malignancies. Several of these diseases, such as myelodysplastic syndromes (MDSs), are responsive to DNA methyltransferase inhibitors. To determine the extent of promoter hypermethylation in such tumors, we compared the distribution of DNA methylation of 14 000 promoters in MDS and secondary acute myeloid leukemia (AML) patients enrolled in a phase 1 trial of 5-azacyt ...[more]