Ontology highlight
ABSTRACT:
SUBMITTER: Wagner CE
PROVIDER: S-EPMC2765782 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Wagner Carl E CE Jurutka Peter W PW Marshall Pamela A PA Groy Thomas L TL van der Vaart Arjan A Ziller Joseph W JW Furmick Julie K JK Graeber Mark E ME Matro Erik E Miguel Belinda V BV Tran Ivy T IT Kwon Jungeun J Tedeschi Jamie N JN Moosavi Shahram S Danishyar Amina A Philp Joshua S JS Khamees Reina O RO Jackson Jevon N JN Grupe Darci K DK Badshah Syed L SL Badshah Syed L SL Hart Justin W JW
Journal of medicinal chemistry 20091001 19
This report describes the synthesis of analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (1), commonly known as bexarotene, and their analysis in acting as retinoid X receptor (RXR)-specific agonists. Compound 1 has FDA approval to treat cutaneous T-cell lymphoma (CTCL); however, its use can cause side effects such as hypothyroidism and increased triglyceride concentrations, presumably by disruption of RXR heterodimerization with other nuclear receptors. ...[more]