Ontology highlight
ABSTRACT:
SUBMITTER: Martinez C
PROVIDER: S-EPMC4027779 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Martínez Claudio C Lieb Michele M Alvarez Susana S Rodríguez-Barrios Fátima F Alvarez Rosana R Khanwalkar Harshal H Gronemeyer Hinrich H de Lera Angel R AR
ACS medicinal chemistry letters 20140319 5
Arotinoids containing a C5,C8-diphenylnaphthalene-2-yl ring linked to a (C3-halogenated) benzoic acid via an ethenyl connector (but not the corresponding naphthamides), which are prepared by Horner-Wadsworth-Emmons reaction of naphthaldehydes and benzylphosphonates, display the rather unusual property of being RXR agonists (15-fold induction of the RXR reporter cell line was achieved at 3- to 10-fold lower concentration than 9-cis-retinoic acid) and RAR antagonists as shown by transient transact ...[more]