Ontology highlight
ABSTRACT:
SUBMITTER: Yan F
PROVIDER: S-EPMC2765915 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Yan Funing F Che Fa-Yun FY Rykunov Dmitry D Nieves Edward E Fiser Andras A Weiss Louis M LM Hogue Angeletti Ruth R
Analytical chemistry 20090901 17
Cross-linking analysis of protein complexes and structures by tandem mass spectrometry (MS/MS) has advantages in speed, sensitivity, specificity, and the capability of handling complicated protein assemblies. However, detection and accurate assignment of the cross-linked peptides are often challenging due to their low abundance and complicated fragmentation behavior in collision-induced dissociation (CID). To simplify the MS analysis and improve the signal-to-noise ratio of the cross-linked pept ...[more]