Ontology highlight
ABSTRACT:
SUBMITTER: Batsi C
PROVIDER: S-EPMC2765928 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Batsi Christina C Markopoulou Soultana S Vartholomatos George G Georgiou Ioannis I Kanavaros Panagiotis P Gorgoulis Vassilis G VG Marcu Kenneth B KB Kolettas Evangelos E
Mechanisms of ageing and development 20090503 7
Normal cells divide for a limited number of generations, after which they enter a state of irreversible growth arrest termed replicative senescence. While replicative senescence is due to telomere erosion, normal human fibroblasts can undergo stress-induced senescence in response to oncogene activation, termed oncogene-induced senescence (OIS). Both, replicative and OIS, initiate a DNA damage checkpoint response (DDR) resulting in the activation of the p53-p21(Cip1/Waf1) pathway. However, while ...[more]