Ontology highlight
ABSTRACT:
SUBMITTER: Lagor WR
PROVIDER: S-EPMC2766561 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Lagor William R WR Brown Robert J RJ Toh Sue-Anne SA Millar John S JS Fuki Ilia V IV de la Llera-Moya Margarita M Yuen Tiffany T Rothblat George G Billheimer Jeffrey T JT Rader Daniel J DJ
Arteriosclerosis, thrombosis, and vascular biology 20081113 1
<h4>Objective</h4>Apolipoprotein F (ApoF) is a protein component of several lipoprotein classes including HDL. It is also known as lipid transfer inhibitor protein (LTIP) based on its ability to inhibit lipid transfer between lipoproteins ex vivo. We sought to investigate the role of ApoF in HDL metabolism.<h4>Methods and results</h4>Adeno-associated viruses (AAV) based on serotype 8, were used to overexpress either murine or human ApoF in mice. Overexpression of murine ApoF significantly reduce ...[more]