Ontology highlight
ABSTRACT:
SUBMITTER: Qin Y
PROVIDER: S-EPMC2767171 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Qin Yingying Y Zhao Han H Kovanci Ertug E Simpson Joe Leigh JL Chen Zi-Jiang ZJ Rajkovic Aleksandar A
Fertility and sterility 20070405 5
NANOS3 encodes an RNA-binding protein and has a conserved function in germ cell development. Our objective was to investigate whether mutations in NANOS3 were present in Chinese and Caucasian women with premature ovarian failure. A known synonymous single-nucleotide polymorphism (rs 2016163) in exon 1 was identified through sequencing 80 Chinese and 88 Caucasian women with premature ovarian failure. No additional single-nucleotide polymorphisms or mutations were found in exons encoding for NANOS ...[more]