Ontology highlight
ABSTRACT:
SUBMITTER: Qin Y
PROVIDER: S-EPMC2680741 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Qin Yingying Y Zhao Han H Kovanci Ertug E Simpson Joe Leigh JL Chen Zi-Jiang ZJ Rajkovic Aleksandar A
Fertility and sterility 20070710 4
The LHX8 (LIM homeobox 8) gene encodes a LIM homeodomain transcriptional regulator that is preferentially expressed in germ cells and critical for mammalian oogenesis. The authors investigated whether nucleotide changes were present in the LHX8 gene of Caucasian women with premature ovarian failure (POF), as compared with control women. When the authors sequenced 95 Caucasian women with POF, they discovered two novel single-nucleotide polymorphisms (SNPs) in intron 3 (c.769+10G>T) and 3' untrans ...[more]