Ontology highlight
ABSTRACT:
SUBMITTER: Ivanova MM
PROVIDER: S-EPMC2767333 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Ivanova Margarita M MM Mazhawidza Williard W Dougherty Susan M SM Minna John D JD Klinge Carolyn M CM
Molecular and cellular endocrinology 20090207 1-2
Gender differences in lung disease and cancer are well-established. We reported estrogenic transcriptional responses in lung adenocarcinoma cells from females but not males despite similar estrogen receptor (ER) expression. Here we tested the hypothesis that normal human bronchial epithelial cells (HBECs) show gender-independent estrogenic responses. We report that a small sample of HBECs express approximately twice as much ERbeta as ERalpha. ERalpha and ERbeta were located in the cytoplasm, nuc ...[more]