Ontology highlight
ABSTRACT:
SUBMITTER: Miller KK
PROVIDER: S-EPMC3529809 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Miller Kristy K Michael KK Al-Rayyan Numan N Ivanova Margarita M MM Mattingly Kathleen A KA Ripp Sharon L SL Klinge Carolyn M CM Prough Russell A RA
Steroids 20121102 1
Dehydroepiandrosterone (DHEA) levels were reported to associate with increased breast cancer risk in postmenopausal women, but some carcinogen-induced rat mammary tumor studies question this claim. The purpose of this study was to determine how DHEA and its metabolites affect estrogen receptors α or β (ERα or ERβ)-regulated gene transcription and cell proliferation. In transiently transfected HEK-293 cells, androstenediol, DHEA, and DHEA-S activated ERα. In ERβ transfected HepG2 cells, androsten ...[more]