Ontology highlight
ABSTRACT:
SUBMITTER: Hartenstein B
PROVIDER: S-EPMC2767339 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Hartenstein Bettina B Dittrich Bernd Thilo BT Stickens Dominique D Heyer Babette B Vu Thiennu H TH Teurich Sibylle S Schorpp-Kistner Marina M Werb Zena Z Angel Peter P
The Journal of investigative dermatology 20060201 2
Degradation of the extracellular matrix, which is an indispensable step in tissue remodelling processes such as embryonic development and wound healing of the skin, has been attributed to collagenolytic activity of members of the matrix metalloproteinase family (MMPs). Here, we employed mmp13 knockout mice to elucidate the function of MMP13 in embryonic skin development, skin homeostasis, and cutaneous wound healing. Overall epidermal architecture and dermal composition of non-injured skin were ...[more]