Ontology highlight
ABSTRACT:
SUBMITTER: Yuasa M
PROVIDER: S-EPMC5978876 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Yuasa Masato M Saito Masanori M Molina Cesar C Moore-Lotridge Stephanie N SN Benvenuti Michael A MA Mignemi Nicholas A NA Okawa Atsushi A Yoshii Toshitaka T Schwartz Herbert S HS Nyman Jeffry S JS Schoenecker Jonathan G JG
PloS one 20180531 5
Immediately following a fracture, a fibrin laden hematoma is formed to prevent bleeding and infection. Subsequently, the organized removal of fibrin, via the protease plasmin, is essential to permit fracture repair through angiogenesis and ossification. Yet, when plasmin activity is lost, the depletion of fibrin alone is insufficient to fully restore fracture repair, suggesting the existence of additional plasmin targets important for fracture repair. Previously, activated matrix metalloproteina ...[more]