Ontology highlight
ABSTRACT:
SUBMITTER: Chen S
PROVIDER: S-EPMC2768491 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Chen Siyuan S Smith Lloyd M LM
Langmuir : the ACS journal of surfaces and colloids 20091001 20
The ability to pattern small molecules and proteins on artificial surfaces is of importance for the development of new tools including tissue engineering, cell-based drug screening, and cell-based sensors. We describe here a novel "caged" thiol-mediated strategy for the fabrication of planar substrates patterned with biomolecules using photolithography. A thiol-bearing phosphoramidite (3-(2'-nitrobenzyl)thiopropyl (NBTP) phosphoramidite) was synthesized and coupled to a hydroxyl-terminated amorp ...[more]