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Mammalian glycosylation in immunity.

ABSTRACT: Glycosylation produces a diverse and abundant repertoire of glycans, which are collectively known as the glycome. Glycans are one of the four fundamental macromolecular components of all cells, and are highly regulated in the immune system. Their diversity reflects their multiple biological functions that encompass ligands for proteinaceous receptors known as lectins. Since the discovery that selectins and their glycan ligands are important for the regulation of leukocyte trafficking, it has been shown that additional features of the vertebrate immune system are also controlled by endogenous cellular glycosylation. This Review focuses on the emerging immunological roles of the mammalian glycome.

SUBMITTER: Marth JD

PROVIDER: S-EPMC2768770 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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Mammalian glycosylation in immunity.

Marth Jamey D JD Grewal Prabhjit K PK

Nature reviews. Immunology 20081101 11

Glycosylation produces a diverse and abundant repertoire of glycans, which are collectively known as the glycome. Glycans are one of the four fundamental macromolecular components of all cells, and are highly regulated in the immune system. Their diversity reflects their multiple biological functions that encompass ligands for proteinaceous receptors known as lectins. Since the discovery that selectins and their glycan ligands are important for the regulation of leukocyte trafficking, it has bee ...[more]

PMID: 18846099

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