Ontology highlight
ABSTRACT:
SUBMITTER: Taga ME
PROVIDER: S-EPMC2770582 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Taga Michiko E ME Larsen Nicholas A NA Howard-Jones Annaleise R AR Walsh Christopher T CT Walker Graham C GC
Nature 20070301 7134
Vitamin B12 (cobalamin) is among the largest known non-polymeric natural products, and the only vitamin synthesized exclusively by microorganisms. The biosynthesis of the lower ligand of vitamin B(12), 5,6-dimethylbenzimidazole (DMB), is poorly understood. Recently, we discovered that a Sinorhizobium meliloti gene, bluB, is necessary for DMB biosynthesis. Here we show that BluB triggers the unprecedented fragmentation and contraction of the bound flavin mononucleotide cofactor and cleavage of th ...[more]