Ontology highlight
ABSTRACT:
SUBMITTER: Petzold T
PROVIDER: S-EPMC2770750 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Petzold Tobias T Orr A Wayne AW Hahn Cornelia C Jhaveri Krishna A KA Parsons J Thomas JT Schwartz Martin Alexander MA
American journal of physiology. Cell physiology 20090708 4
Atherogenesis involves activation of NF-kappaB in endothelial cells by fluid shear stress. Because this pathway involves integrins, we investigated the involvement of focal adhesion kinase (FAK). We found that FAK was not required for flow-stimulated translocation of the p65 NF-kappaB subunit to the nucleus but was essential for phosphorylation of p65 on serine 536 and induction of ICAM-1, an NF-kappaB-dependent gene. NF-kappaB activation by TNF-alpha or hydrogen peroxide was FAK independent. Ev ...[more]