Synthesis of fluorogenic polymers for visualizing cellular internalization.
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ABSTRACT:
SUBMITTER: Mangold SL
PROVIDER: S-EPMC2771217 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Publications
Synthesis of fluorogenic polymers for visualizing cellular internalization.
Mangold Shane L SL Carpenter Rachael T RT Kiessling Laura L LL
Organic letters 20080619 14
The binding of a polymeric ligand to a cell surface receptor can promote its internalization. Methods to track and visualize multivalent ligands within a cell can give rise to new therapeutic strategies and illuminate signaling processes. We have used the features of the ring-opening metathesis polymerization (ROMP) to develop a general strategy for synthesizing multivalent ligands equipped with a latent fluorophore. The utility of ligands of this type is highlighted by visualizing multivalent a ...[more]
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