Ontology highlight
ABSTRACT:
SUBMITTER: Graham RR
PROVIDER: S-EPMC2772171 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Nature genetics 20080901 9
Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 x 10(-12), OR = 2.29). We also found evidence of two independent signals near TNFAIP3 associated with SLE, including one previously associated with rheumatoid arthritis (RA). These results establish that variants near TNFAIP3 ...[more]