Ontology highlight
ABSTRACT:
SUBMITTER: Harley IT
PROVIDER: S-EPMC2914299 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Harley Isaac T W IT Niewold Timothy B TB Stormont Rebecca M RM Kaufman Kenneth M KM Glenn Stuart B SB Franek Beverly S BS Kelly Jennifer A JA Kilpatrick Jeffrey R JR Hutchings David D Divers Jasmin J Bruner Gail R GR Edberg Jeffrey C JC McGwin Gerald G Petri Michelle A MA Ramsey-Goldman Rosalind R Reveille John D JD Vilá-Pérez Luis M LM Merrill Joan T JT Gilkeson Gary S GS Vyse Timothy J TJ Alarcón-Riquelme Marta E ME Cho Soo-Kyung SK Jacob Chaim O CO Alarcón Graciela S GS Moser Kathy L KL Gaffney Patrick M PM Kimberly Robert P RP Bae Sang-Cheol SC Langefeld Carl D CD Harley John B JB Guthridge Joel M JM James Judith A JA
Journal of biomedicine & biotechnology 20100715
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by increased type I interferons (IFNs) and multiorgan inflammation frequently targeting the skin. IFN-kappa is a type I IFN expressed in skin. A pooled genome-wide scan implicated the IFNK locus in SLE susceptibility. We studied IFNK single nucleotide polymorphisms (SNPs) in 3982 SLE cases and 4275 controls, composed of European (EA), African-American (AA), and Asian ancestry. rs12553951C was associated with SLE in ...[more]