Ontology highlight
ABSTRACT:
SUBMITTER: Siegenthaler JA
PROVIDER: S-EPMC2772834 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Siegenthaler Julie A JA Ashique Amir M AM Zarbalis Konstantinos K Patterson Katelin P KP Hecht Jonathan H JH Kane Maureen A MA Folias Alexandra E AE Choe Youngshik Y May Scott R SR Kume Tsutomu T Napoli Joseph L JL Peterson Andrew S AS Pleasure Samuel J SJ
Cell 20091001 3
Extrinsic signals controlling generation of neocortical neurons during embryonic life have been difficult to identify. In this study we demonstrate that the dorsal forebrain meninges communicate with the adjacent radial glial endfeet and influence cortical development. We took advantage of Foxc1 mutant mice with defects in forebrain meningeal formation. Foxc1 dosage and loss of meninges correlated with a dramatic reduction in both neuron and intermediate progenitor production and elongation of t ...[more]