Systematic generation of biophysically detailed models for diverse cortical neuron types.
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ABSTRACT:
SUBMITTER: Gouwens NW
PROVIDER: S-EPMC5818534 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Systematic generation of biophysically detailed models for diverse cortical neuron types.
Gouwens Nathan W NW Berg Jim J Feng David D Sorensen Staci A SA Zeng Hongkui H Hawrylycz Michael J MJ Koch Christof C Arkhipov Anton A
Nature communications 20180219 1
The cellular components of mammalian neocortical circuits are diverse, and capturing this diversity in computational models is challenging. Here we report an approach for generating biophysically detailed models of 170 individual neurons in the Allen Cell Types Database to link the systematic experimental characterization of cell types to the construction of cortical models. We build models from 3D morphologies and somatic electrophysiological responses measured in the same cells. Densities of a ...[more]
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