Ontology highlight
ABSTRACT:
SUBMITTER: Merkel OM
PROVIDER: S-EPMC2773017 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Merkel Olivia M OM Mintzer Meredith A MA Sitterberg Johannes J Bakowsky Udo U Simanek Eric E EE Kissel Thomas T
Bioconjugate chemistry 20090901 9
A family of generation 1, 2, and 3 triazine dendrimers differing in their core flexibility was prepared and evaluated for their ability to accomplish gene transfection. Dendrimers and dendriplexes were analyzed by their physicochemical and biological properties such as condensation of DNA, size, surface charge, morphology of dendriplexes, toxic and hemolytic effects, and ultimately transfection efficiency in L929 and MeWo cells. Flexibility of the backbone was found to play an important role wit ...[more]