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Pd-catalyzed conversion of aryl chlorides, triflates, and nonaflates to nitroaromatics.

ABSTRACT: An efficient Pd catalyst for the transformation of aryl chlorides, triflates, and nonaflates to nitroaromatics has been developed. This reaction proceeds under weakly basic conditions and displays a broad scope and excellent functional group compatibility. Moreover, this method allows for the synthesis of aromatic nitro compounds that cannot be accessed efficiently via other nitration protocols. Mechanistic insight into the transmetalation step of the catalytic process is also reported.

SUBMITTER: Fors BP

PROVIDER: S-EPMC2773681 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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Pd-catalyzed conversion of aryl chlorides, triflates, and nonaflates to nitroaromatics.

Fors Brett P BP Buchwald Stephen L SL

Journal of the American Chemical Society 20090901 36

An efficient Pd catalyst for the transformation of aryl chlorides, triflates, and nonaflates to nitroaromatics has been developed. This reaction proceeds under weakly basic conditions and displays a broad scope and excellent functional group compatibility. Moreover, this method allows for the synthesis of aromatic nitro compounds that cannot be accessed efficiently via other nitration protocols. Mechanistic insight into the transmetalation step of the catalytic process is also reported. ...[more]

PMID: 19737014

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