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An improved catalyst system for the Pd-catalyzed fluorination of (hetero)aryl triflates.

ABSTRACT: The stable Pd(0) species [(1,5-cyclooctadiene)(L·Pd)2] (L = AdBrettPhos) has been prepared and successfully evaluated as a precatalyst for the fluorination of aryl triflates derived from biologically active and heteroaryl phenols, challenging substrates for our previously reported catalyst system. Additionally, this precatalyst activates at room temperature under neutral conditions, generates 1,5-cyclooctadiene as the only byproduct, and leads to overall cleaner reaction profiles.

SUBMITTER: Lee HG

PROVIDER: S-EPMC3858322 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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An improved catalyst system for the Pd-catalyzed fluorination of (hetero)aryl triflates.

Lee Hong Geun HG Milner Phillip J PJ Buchwald Stephen L SL

Organic letters 20131018 21

The stable Pd(0) species [(1,5-cyclooctadiene)(L·Pd)2] (L = AdBrettPhos) has been prepared and successfully evaluated as a precatalyst for the fluorination of aryl triflates derived from biologically active and heteroaryl phenols, challenging substrates for our previously reported catalyst system. Additionally, this precatalyst activates at room temperature under neutral conditions, generates 1,5-cyclooctadiene as the only byproduct, and leads to overall cleaner reaction profiles. ...[more]

PMID: 24138611

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