Ontology highlight
ABSTRACT:
SUBMITTER: Costanzo-Garvey DL
PROVIDER: S-EPMC2773684 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Costanzo-Garvey Diane L DL Pfluger Paul T PT Dougherty Michele K MK Stock Jeffery L JL Boehm Matthew M Chaika Oleg O Fernandez Mario R MR Fisher Kurt K Kortum Robert L RL Hong Eun-Gyoung EG Jun John Y JY Ko Hwi Jin HJ Schreiner Aimee A Volle Deanna J DJ Treece Tina T Swift Amy L AL Winer Mike M Chen Denise D Wu Min M Leon Lisa R LR Shaw Andrey S AS McNeish John J Kim Jason K JK Kim Jason K JK Morrison Deborah K DK Tschöp Matthias H MH Lewis Robert E RE
Cell metabolism 20091101 5
Kinase suppressors of Ras 1 and 2 (KSR1 and KSR2) function as molecular scaffolds to potently regulate the MAP kinases ERK1/2 and affect multiple cell fates. Here we show that KSR2 interacts with and modulates the activity of AMPK. KSR2 regulates AMPK-dependent glucose uptake and fatty acid oxidation in mouse embryonic fibroblasts and glycolysis in a neuronal cell line. Disruption of KSR2 in vivo impairs AMPK-regulated processes affecting fatty acid oxidation and thermogenesis to cause obesity. ...[more]