Ontology highlight
ABSTRACT:
SUBMITTER: Marinangeli C
PROVIDER: S-EPMC6203244 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Marinangeli Claudia C Didier Sébastien S Ahmed Tariq T Caillerez Raphaelle R Domise Manon M Laloux Charlotte C Bégard Séverine S Carrier Sébastien S Colin Morvane M Marchetti Philippe P Ghesquière Bart B Balschun Detlef D Buée Luc L Kluza Jérôme J Vingtdeux Valérie V
iScience 20181012
Although the brain accounts for only 2% of the total body mass, it consumes the most energy. Neuronal metabolism is tightly controlled, but it remains poorly understood how neurons meet their energy demands to sustain synaptic transmission. Here we provide evidence that AMP-activated protein kinase (AMPK) is pivotal to sustain neuronal energy levels upon synaptic activation by adapting the rate of glycolysis and mitochondrial respiration. Furthermore, this metabolic plasticity is required for th ...[more]