Ontology highlight
ABSTRACT:
SUBMITTER: Sarkar K
PROVIDER: S-EPMC2774037 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Sarkar Kakali K Fox-Talbot Karen K Steenbergen Charles C Bosch-Marcé Marta M Semenza Gregg L GL
Proceedings of the National Academy of Sciences of the United States of America 20091019 44
Diabetes is a major risk factor for ischemic disease. Treatment options for diabetic patients with peripheral arterial disease when revascularization is not possible are limited, resulting in a high incidence of limb amputation. We evaluated the therapeutic potential of AdCA5, an adenovirus encoding a constitutively active form of HIF-1alpha, in a diabetic model of critical limb ischemia. Diabetic db/db and nondiabetic db/+ mice were subjected to unilateral femoral artery ligation. Limb perfusio ...[more]